Multiple times each day, we all reach for an upper. It may be a piece of chocolate, an espresso, a Coke, a candy bar. After a day of stressful work, we often switch to a downer: a cocktail, a beer, or a marijuana joint (now legal in at least eight states). All of these are brain supplements, neural nutrition, or attitude modifiers. And where do you think this constant up-and-down, unscientific brain modulation is leading?