Growth and Bioactive Factors with Lubrication: Injections To Accelerate Healing

At The Stone Clinic, an evolution of injectable regenerative therapy has occurred. We started with blood injections in the 1990’s intuiting that the blood had all the healing components required. This evolved to isolating the platelets in blood that release the most important growth factors. These growth factors act to both directly stimulate healing and to recruit stem derived self-repair cells from the walls of vessels to migrate to the site of injury. Today growth factors from platelets drawn from the patient in the office combined with bioactive factors from amniotic fluid and hyaluronic acid constitute an important part of our injection therapies.

Hyaluronic acid is the normal joint lubrication material found in all joints. By injecting a syringe full into the knee many patients find relief from pain and inflammation, but the response is variable. We choose to augment the lubrication injections with bioactive factors from platelets or amniotic fluid to potentiate the biologic response.


  • PRP: growth factors derived from platelets

  • Hyaluronic Acid

    • In acute injuries, our preference is to augment healing with PRP or amniotic fluid.

    • In arthritis, we prefer to add hyaluronic acid to the PRP or amniotic fluid injections.


The risk of any joint injection is possible infection or reaction. For each of these preparations the risk is extremely low but not zero. The amniotic fluid is from healthy mothers at C-section fully tested for all known diseases and provided by an approved tissue bank. The Stone Clinic and Stone Research Foundation collaborate to push forward the research and development that can improve the efficacy and document the outcomes of this regenerative therapy.