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Z-Lig ACL replacement patient stories

ACL reconstruction using the Z-lig replacement device

The Z-Lig is an off the shelf natural tissue ACL replacement device allowing the reconstruction of the Anterior Cruciate Ligament without needing to use a patient's own tissue.

ACL reconstruction using Z-lig, a natural tissue alternative | Patient Story- 12 years post op

Our patient Mike ruptured his right ACL while Limbo dancing at a wedding. He had it repaired using the Z-lig ligament replacement device engineered from porcine tissue. Previously, Mike had ruptured his left ACL and had it repaired using an autograft from his own patella tendon. "The experiences could not have been more different" he says. Unlike the autograft, the Z-lig procedure and the recovery was minimal. "In fact, I was a bit worried because my knee was so stable and so pain free that I thought I might damage the knee somehow because it felt so good so soon!" He now does all the things he does before the surgery, league basketball, coaches baseball, plays with his dog. In fact, he says "because of the physical therapy and the activities I went though, I think it's better than it was before the injury"

ACL reconstruction using Z-lig, a natural tissue alternative | Patient Story- 13 years post op

ACL reconstruction using Z-lig, a natural tissue alternative | Patient Story- 13 years post op

ACL reconstruction for pro-skier using Z-lig, a natural alternative tissue - 11 years post op

In 2002, Canadian Pro Skier Rick Lewon had his right ACL reconstructed by Dr. Kevin Stone, using a Z-lig replacement device a natural alternative tissue engineered from porcine tissue.. Dr. Stone's treatment was a medical breakthrough and the first non-human biologic method for ACL reconstruction of the knee. After this surgery, Lewon went on to win numerous Canadian Downhill Masters titles. 11 years later, his Xenograft is still going strong and is doing a lot better than the ACL reconstruction he had done on his left leg, which used his own hamstring. Lewon says he is hoping to one day get the Z-lig on on that knee too.

ACL reconstruction using Z-lig, a natural alternative tissue | Patient Story - 13 years post op

One of the first patients in the world to have a xenograft ligament replacement using porcine tissue, Canadian Pro Skier Rick Lewon had his right ACL reconstructed by Dr. Kevin Stone. After this surgery, Lewon went on to win numerous Canadian Downhill Masters titles. Now 13 years later the Z-lig, is still going strong and is doing a lot better than the ACL reconstruction he had done on his left leg, which used his own hamstring.

Animal ligaments can repair human knees - ABC 7 News Story on Kevin R. Stone's work on the Z-Lig

Bay Area researchers have developed a new technique to help repair injured knees. It could someday change the way many surgeries are done.

From bike riding to basketball, it would be hard to find a sport that Marty doesn't like. But the financial manager, who asked us not use his last name, also paid a painful price with his right knee.

"I'd just torn my ACL playing basketball for the second time in that knee. I had a pretty bad experience the first time, I had a patellar tendon graft, very painful, took a long time getting back to being active," he says.

Marty turned to San Francisco surgeon, Kevin Stone, M.D., who says the grafts typically involve harvesting bone and tendon from the front of the knee, to rebuild the ACL.

"In the 21st century, we shouldn't be taking away one part of a person's body to rebuild the other, it's somewhat barbaric and we know from long term data that we actually hurt the patient when we do that," says Stone.

One strategy is to wait for human donor tissue to become available. But in Marty's case, Stone was able to offer an experimental alternative -- an animal ligament, known as Z-Lig.

"So a Z-Lig is a pig bone patellar tendon bone, so a pig graft that we can use to rebuild the anterior cruciate ligament [ACL] in a human," Stone explains.

But first, Stone's team had to find a way to essentially, "humanize" the tissue to prevent rejection. Researcher Thomas Turek said the solution involved identifying and removing a specific antigen found in animal tissue but not in humans.

"The processing actually removes the cells and lipotropes so the device has no recognition," according to Turek.

The breakthrough allowed Stone to rebuild Marty's ACL with the pig ligament, as part of a pilot study. He believes the Z-Lig has several advantages including consistent quality.

"Now what we can do is take that exact same graft from a young health pig. So we save the patients all the surgical trauma of having their own tissue being used, and we get to have it from a young healthy animal every time," says Stone.

Trial results were successful enough that the Z-Lig received approval for use in Europe. The team now hopes to organize a similar trial in the U.S. for FDA approval.

For Marty, the best part of his rebuilt knee has been forgetting about it. He said, "I feel confident in my knees. In fact, I don't think about it. I feel I can do all the activities I used to do.

Written and produced by Tim Didion - ABC News Bay Area

ACL reconstruction using Z-lig, a natural tissue alternative | Patient Story - 9 years post op

Mike had both of his ACLs replaced at different times with different procedures. He is able to compare what it's like to have his ACLs rebuilt with the Z-lig replacement device vs an autograft (using his own tissue). His first ACL replacement was in his left knee and was done using tissue harvested from his own patella tendon.
5 years later he had a an ACL replacement using the Z-Lig replacement device engineered from porcine tissue. He says the procedures were very different. Mike explains, "The procedure for harvesting the patella tendon was maybe even worse than the surgery itself." He goes on, "The Z-Lig in contrast was in and out." He says if he had to do it over again he'd chose the Z-lig. " I wouldn't even think about it." . Physical therapy was key to both procedures. For more minimally invasive cartilage replacement information please visit http://www.stoneclinic.com

Related videos:

http://www.youtube.com/user/kstonemd
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ACL reconstruction using Z-lig, a natural tissue alternative | Patient Story- 9 years post op

Marlise tore her Anterior Cruciate Ligament (ACL) in a ski accident. She had an ACL reconstruction using a Z-Lig replacement device, a a natural tissue alternative engineered from porcine tissue (rather than relying on scarce human donor tissue or using tissue from her own body such as a patella tendon.) Less than a year after surgery she reported that her knee had full range of motion, no pain and was totally back to normal. She says "It's now 9 years later and I feel great. I ski, I run, I hike, I can do anything I want."

For more cartilage replacement information please visit http://www.stoneclinic.com/ or watch more videos at
http://www.stoneclinic.com/videos-and-media

Related videos:

http://www.youtube.com/user/kstonemd
http://www.youtube.com/watch?v=Uxj5GgmrKmQ
http://www.youtube.com/watch?v=EM0qOEwkIE8
http://www.youtube.com/watch?v=G1M6li3WUBU
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World Champion Ski Racer and Z-Lig Patient for Knee Surgery

For more knee cartilage replacement information please visit http://www.stoneclinic.com/ or watch more videos at
http://www.stoneclinic.com/videos-and-media

Related videos:

http://www.youtube.com/user/kstonemd
http://www.youtube.com/watch?v=Uxj5GgmrKmQ
http://www.youtube.com/watch?v=EM0qOEwkIE8
http://www.youtube.com/watch?v=G1M6li3WUBU
http://www.youtube.com/watch?v=pxgwQmgtzIs
http://www.youtube.com/watch?v=DcaAlIKAQvA
http://www.youtube.com/watch?v=JgYcPnYv394
http://www.youtube.com/watch?v=UecRVA7RrWQ
http://www.youtube.com/watch?v=Jm7BsHaM73c
http://www.youtube.com/watch?v=O3F0gl4MQeQ
http://www.youtube.com/watch?v=vJNHpb4FS2M
http://www.youtube.com/watch?v=aVpDAsikPM4
http://www.youtube.com/watch?v=wGJvlS2HVrk
http://www.youtube.com/watch?v=yXy4AUf9h_U
http://www.youtube.com/watch?v=y5SYb9qaMk0
http://www.youtube.com/watch?v=GK56j-noMFg
http://www.youtube.com/watch?v=l5rBhmgnCds
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