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BIOLOGICAL
KNEE REPLACEMENT WITH ARTICULAR CARTILAGE PASTE GRAFT, MENISCAL ALLOGRAFT AND
OPENING WEDGE OSTEOTOMY
K.R.
Stone, M.D., A. Walgenbach, R.N., N.P., M.S.N.
Unicompartmental
knee arthritis has usually been treated with conservative care followed by arthroscopic
debridements, osteotomies, and eventually joint replacement. Many patients try
to defer joint replacement and some request efforts at cartilage replacement.
We have sought to improve our treatment of unicompartmental arthritis by combining
new techniques of articular cartilage repair, meniscus allograft replacement and
medial opening wedge osteotomy into a single outpatient procedure. We have called
this, "Biologic Joint Replacement." Recognizing that these techniques are in their
infancy, we present our surgical technique and the initial successes and failures
at resurfacing arthritic joints in active people.
Since 1991 we have performed our technique of articular cartilage paste grafting
on 124 patients. Of these patients, 32 underwent concurrent meniscal allograft
replacements and 14 underwent medial opening wedge osteotomies to correct varus
alignment. The combined surgical technique of articular cartilage paste grafting,
a new technique of meniscal allograft insertion, and our technique of medial opening
wedge osteotomy will be presented in detail. The inclusion criteria for these
patients were predominately uni-compartmental arthritic changes with pain at the
joint line and failure of conservative care. This conservative care typically
includes NSAID's, cortisone, heel wedges, activity modification, and physical
therapy. The patient had to verbalize a willingness to undergo unproven procedures
that might lead to an earlier joint replacement.
At
an average follow-up of two years in this mixed population with multiple concomitant
procedures, the pain relief, activity levels, WOMAC, ADLS, and Tegner scores have
improved significantly. Second-look arthroscopies in 35 patients have demonstrated
healed articular cartilage surfaces with a mixture of hyaline and fibrocartilage
demonstrated by biopsy with histology, collagen typing and gel electrophoresis
analysis. Five paste grafts have failed, and four have gone onto partial joint
replacement with one having total joint replacement. Six of 47 meniscal allografts
have re-torn. Three osteotomies have failed to obtain adequate correction with
one being revised. In this complicated patient population, symptomatic relief
can be obtained at this evaluation period. As the techniques improve and longer
follow-up is obtained, the role of these combined procedures will be determined.
The Stone Clinic
3727 Buchanan Street • San
Francisco CA 94123 • info@stoneclinic.com • (415)
563-3110