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Stone Clinic Podcasts

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Biologic Knee Replacement: Meniscus Transplantation

Description:
Kevin R. Stone, M.D., discusses the meniscus: what it is, why it is important, and what to do if you injure it. Followed by a patient Q&A. 12:19 minutes/11.3MB
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I am Dr. Kevin Stone, orthopaedic surgeon at The Stone Clinic in San Francisco, and this lecture on the meniscus cartilage was recorded on January 25, 2006.

Today, we are talking about the knee joint’s meniscus. The meniscus is the shock absorber inside a knee joint that is very frequently injured in sports activities. The shock absorber is a fibrous cartilage that sits between the femur and the tibia. There is a medial meniscus, meaning the inside one, and a lateral meniscus, an outside meniscus. The shock absorbers permit the knee joint to go through one – three million steps per year at up to five times body weight without the joint wearing out, under normal activity.

The fibrous shock absorbers, when injured, produce a rough surface inside the knee, which causes catching, locking, buckling, pain, or any combination of the above symptoms inside the knee joint. The meniscus can be injured in sports and twisting activities, such as planting a foot on a soccer field and then being hit from the side, or it can be injured in simple activities, such as getting out of the car, placing the foot on the ground, stepping up and twisting on the knee, and feeling a sudden catch or pop.

When injured, the meniscus is most commonly torn. If it is torn in a clear, clean pattern, it can frequently be repaired arthroscopically. If it is torn in a complex or degenerative pattern, it very often needs to be trimmed. How the meniscus is treated determines the outcome for the knee joint. For instance, if a person injures his knee by twisting it and suffering a torn meniscus and then lives with the knee pain, catching, locking, or giving way for many months, that meniscus will be beaten up, torn, and degenerated. This will often cause a wear pattern against the opposing articular cartilage, the covering of the bone inside the joint. That wear pattern is what we call arthritis. Then, if a patient presents to a surgeon with a complaint of knee pain, catching, popping, and/or giving way, and a surgeon examines that knee, reproducing that pain or catching, we will most commonly order a Magnetic Resonance Image, or MRI, of the knee.

The MRI will show the fibrous shock absorber, the meniscus, and the tear pattern. Then, upon deciding to treat the meniscus, an outpatient, arthroscopic procedure can be performed, where a patient goes to an outpatient surgery center and, under a local or general anesthesia, the surgeon looks inside the knee with an arthroscope, examining the torn meniscus cartilage and deciding, at that time, whether to trim away the damaged tissue or repair it with sutures. The cleaner and fresher the tear or the younger the tissue, the easier it is to repair and save the meniscus cartilage, which is generally the best option for the knee joint because saving the meniscus permits the normal shock absorber to heal and protect the knee joint over time. However, if it is a degenerative, torn, shattered meniscus, trimming the meniscus is a more common procedure. How the surgeon trims the meniscus and how much meniscus is lost will often determine the outcome of the surgery and the long-term results for the knee. If the meniscus can be shaved carefully and artfully back into a shape very similar to its normal shape, then the knee joint will, most likely, not miss the missing meniscus cartilage. That’s where arthroscopic surgery is both a science, determining what to do to treat the meniscus, and an art, how good is the surgeon at shaping and trimming that meniscus, how important does he perceive it to be, and how easy it is to perform in that individual patient’s knee.

The meniscus is torn about one million times per year in the United States, leading to out-patient arthroscopic surgeries about 1.4 million times just for that one torn meniscus cartilage tissue. It is an extremely common event and, most of the time, patient’s do very well. Unfortunately, sometimes, if the meniscus cartilage is significantly damaged and a lot of it needs to be removed, the patient will suffer pain and eventually arthritis, the wearing away of the cartilage in the joint. Then, the patient asks the surgeon, “Isn’t there something else you can put back into the knee joint to cushion the bones and replace the meniscus?” Today, we most commonly do that with a meniscus allograft, a donor meniscus cartilage that we take from a cadaver and insert back into the knee, sew into place, and thus provide a new shock absorber for that knee joint, replacing the missing meniscus. Traditionally, it was thought that you could not replace the meniscus if the knee had already become arthritic. However, here at The Stone Clinic over the last ten years, we have been conducting a study of the survival of meniscus cartilage in arthritic joints and have demonstrated in the first part of the study, a two to seven year follow-up, that the meniscus can survive in an arthritic joint, if it is sewn in carefully, a host of specific rehabilitation programs are followed, and the opposing arthritic surfaces are treated, very commonly with a grafting procedure called a paste graft, which helps restore that articular cartilage. We will have another conversation about paste grafting at a later lecture.

For today however, the focus is on the meniscus cartilage, how it is injured, how it is saved, what the biology is, and what the replacement options are for the future. It should be noted that soon in the future there will be replacement options for replacing portions of the meniscus and that is called a collagen meniscus implant, which was also invented here, at The Stone Clinic, and first tested in early 1991. It is now for sale in Europe, Chile, and Australia and is finishing clinical trials here in the United States. It will most likely end up being a partial replacement for the meniscus cartilage. I hope this has been helpful and I look forward to answering any questions that someone might have.

Q: Dr. Stone, when athletes routinely pound the meniscus through running, cycling, or other sports, it will deteriorate over time. After how long or at what age would they anticipate the meniscus will be so deteriorated that it will no longer function successfully?

Actually, it turns out that, in a normal knee joint, one that has not been injured, the meniscus cartilage and the articular cartilage do not normally degenerate and do not develop arthritis, unless, there is a genetic predisposition to arthritis or there is some other cause.

In an injured knee joint, where rough surfaces are present or where the meniscus has been injured by an impact lesion, then the meniscus goes on to either degenerative tear or frank tear that causes injury and subsequent pain or arthritis. But a normal knee can take running forever, as long as there are good genes involved.

Q: Dr. Stone, are there any tests available to tell how well or how poorly my meniscus is doing?

An orthopaedic surgeon can examine your knee and tell whether or not there are rough areas, catching, or popping inside the joint. An MRI can be performed, which studies the structure of the cartilage, the surfaces, and all the other tissues around the joint. It can give a very accurate indication of the health of the tissue, as long as it is a high quality MRI, focused on knee joint specific anatomy. An x-ray, a plain x-ray, can give an indication of the health of the joint by looking at the joint space present between the bones but it does not specifically look at the meniscus cartilage itself.

Q: Dr. Stone, a friend of mine has had his meniscus removed years ago. Is he a candidate for the meniscus allograft that you talked about, the cadaveric transplantation?

Possibly, when people have lost their meniscus and they develop knee pain at the site of the meniscus cartilage, then those are the most common patients who seek us out, here at the clinic in San Francisco for meniscus cartilage transplantation. The common story is that they were playing football in college, injured their knee, a surgeon removed the meniscus, they went on to play for another 10 or 15 years, and now they have joint pain at that site. That’s the most common person presenting for a meniscus replacement surgery in our practice. The other people who present are the young person, who unfortunately tears it and the surgeon had to remove the meniscus cartilage or the older person who is looking for shock absorption, in order to delay the time for joint arthroplasty or joint replacement.

Q: Dr. Stone, my mother has been told that she is a candidate for joint replacement. Is there any way that this meniscus allograft can keep her from having that operation?

Meniscus replacement can be done in older people with arthritis, as a way to buy time or delay the time at which an artificial joint might be placed in the knee. This clearly depends on the patient, how much arthritis there is in the knee, and whether or not the patient is able to participate in a careful rehab and exercise program. But we have been pleasantly surprised by some of our patients who have pushed us hard and said, “Listen, Doc, I’m not going to let you put an artificial knee in, not yet anyhow. I still want to run, or play volleyball, or play tennis, and be really active. I’d like you to put something biologic in there and, even if it only lasts me five years, that is good enough because I want to keep playing sports.” Those are our patients in their 50s, 60s, and even our 70-year-olds who have pushed us and said, “Look, I want some more athletic time and I would like you to try that.” And we have been pleasantly surprised to see that replacing the shock absorber in the knee, even in some really, significantly arthritic knees has provided those patients with pain relief, shock absorption, and additional years of good use of their knee joint. It doesn’t apply to everyone and we have careful criteria we use when examining the patient, doing our own office MRIs, and working with our physical therapy team to determine which patients would be ideal for this procedure. But we are willing to try it for people who are the right candidates.

The Stone Clinic

3727 Buchanan Street • San Francisco CA 94123 • info@stoneclinic.com • (415) 563-3110

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