You are here

Articular cartilage 2-12 year follow up

Stone, K.R., A.W. Walgenbach, A. Freyer, T.J. Turek, and D.P. Speer. 2006.

"Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: a 2- to 12-year follow-up." Arthroscopy22 (3): 291-299.

PURPOSE: To prospectively assess clinical outcomes and regeneration of osteoarthritic cartilage lesions treated with an articular cartilage paste grafting technique. TYPE OF STUDY: Prospective, longitudinal case series. METHODS: We treated 125 patients (136 procedures; 34% female, 66% male; mean age, 46 years; range, 17 to 73 years) with an Outerbridge classification of grade IV lesions with an articular cartilage paste graft. Clinical data were recorded 2 to 12 years from surgery, with 20 of 145 patients lost to follow-up over 12 years (13.7%). Clinical outcomes were captured annually with validated Western Ontario and McMaster Universities Arthritis Index (WOMAC), International Knee Documentation Committee (IKDC), and Tegner subjective questionnaires. Regenerated cartilage biopsy specimens were obtained at second-look arthroscopy from 66 patients and evaluated as to quality and quantity of defect fill by a blinded, independent histopathology reviewer. RESULTS: Preoperative versus postoperative validated pain, functioning, and activity measures improved significantly (P < .001). Clinically, 18 of the 125 patients were considered failures (14.4%), with 10 patients undergoing subsequent joint arthroplasty and 8 who reported worse pain after surgery. Regional histologic variation occurred. Forty-two of 66 biopsy specimens (63.6%) showed strong and consistent evidence of replacement of their articular surface, and 18 of 66 biopsy specimens (27.3%) showed development of areas of cartilage. CONCLUSIONS: Paste grafting is a low-cost, 1-stage arthroscopic treatment for patients with Outerbridge classification grade IV arthritic chondral lesions. The procedure offers excellent, long-lasting, pain relief, restored functioning, and possibility of tissue regeneration for patients with painful chondral lesions in both arthritic and traumatically injured knees. LEVEL OF EVIDENCE: Level IV, case series.

View this publication by clicking here

Avoid-a-total-knee-replacement-meniscus-transplant-arthritis-repair-stem-cell-paste-graft
We like to do everything possible to rebuild the knee joint with biologic tissues rather than artificial materials to help delay the time in which an artificial joint replacement is necessary.
MCL Injuries:  Why Kevin Durant Will Be Back
There are now phenomenally potent tools to drive healing to a full, faster than ever recovery. You just have to use them.
Orthopedic Research Society Dr. Kevin Stone
As a part of this year’s ORS meeting, Dr. Kevin R. Stone was honored to join Dr. Gordana Vunjak-Novakovic as an invited speaker in a special translational research symposium session entitled “Cartilage Repair: Is it possible?
July 14th, 2015
In light of Wes Matthews and other NBA athletes suffering Achilles ruptures, Dr. Stone speaks to Mavs Moneyball, a...
April 27th, 2016
Dr Stone talking about Steph Curry's injury and the Warrior's season.
December 11th, 2014
"A few select orthopedic surgeons and researchers around the country are pioneering alternate cartilage...

Stone, K.R., A.W. Walgenbach, A. Freyer, T.J. Turek, and D.P. Speer. 2006.

Stone, K.R., A.W. Walgenbach, T.J. Turek, A. Freyer, and M.D. Hill. 2006.

Stone K.R., A.W. Walgenbach, A. Freyer. 2008.